The FDA (Food and Drug Administration) has warned that long term use of proton pump inhibitors, used to treat heart burn (gastroesophageal reflux disease—GERD) may lead to low levels of circulating magnesium. Magnesium is essential to total body wellness, including oral, musculoskeletal, neural and hormonal health. These medications include: esomeprazole magnesium (Nexium), dexlansoprazole (Dexilant), omeprazole (Prilosec), omeprazole and sodium bicarbonate (Zegerid), lansoprazole (Prevacid), pantoprazole sodium (Protonix), rabeprazole sodium (AcipHex) and the combination product esomeprazole magnesium/naproxen (Vimovo). Importantly, in many cases taking a magnesium supplement does not reverse the magnesium deficiency and the only solution is to discontinue the medicine. Ask your doctor to check your magnesium level. Also, do your best to modify your lifestyle/diet to eliminate or minimize the impact of GERD.